what is the most effective treatment for toenail fungus

In an RCT of 135 patients, after 36 weeks’ treatment and 4 weeks’ follow-up (about 40% nail involvement), 7 the cure rate was about 22% (9% with placebo NNT = 8). Topical efinaconazole: In 2 identical RCTs of 1655 patients (48 weeks of treatment, assessed at 52 weeks, about 40% nail involvement), 6 the cure rate was about 16% and about 4% with placebo (NNT of about 9). Topical ciclopirox: In 3 RCTs of 928 patients (48 weeks of treatment and about 40% nail involvement), 4, 5 “cure” (mycologic and clinical cure) rates were 6% to 8% with topical ciclopirox and 0% to 1% with placebo (NNT = 15 to 23). In 15 RCTs, rates were 58% for terbinafine and 46% for azoles (NNT = 9). What are the most effective treatments for toenail fungus Prescription oral antifungal medications Topical nail cream Special antifungal nail polish that. In 9 RCTs, the rate was 31% for “azoles” (mostly itraconazole) and 1.4% for placebo (NNT = 4). In 8 RCTs, rates were 48% for terbinafine and 6% for placebo (number needed to treat of 3). Oral agents: In a meta-analysis of 43 RCTs of 9730 patients taking oral agents 1 (eg, about 60% to 70% nail involvement, 2 12 to 16 weeks of treatment3), the rates of clinical cure after 4 months to 2 years of follow-up were as follows:

What is the most effective treatment for toenail fungus